Wednesday, August 28, 2013
Ask2Pharma
DEFINITION OF PELLETISATION
Pelletization is an agglomeration process, that converts fine powder blend of drug(s) and excipients into small, free flowing, spherical units, referred to as pellets. (Ref. L. Hellen 1992)
The pelletizing process for the production of pharmaceutical pellets - including extrusion and spheronization, production of pellets by powder layering and liquid layering and pelletization via melt and wet granulation processes.
Why Pellet
-Excellent Stability
-Dust free Round pellets
-Good flow behavior
-Easy to dose
-Compact structure
-Very Low hygroscopicity
-High bulk density
-Dense, uniform surface
L-ow abrasion
-High active ingredient content possible
-Optimum starting shape for subsequent coating
-Controlled-release applications
- The risks of the local damage to the GI-tract mucosal
Some Type of Pellets
Liquid layering of pellets-coater systems can all be used to make pellets by layering the active material onto an inert core. Non-pareil starter pellets are sprayed with a solution or suspension of theactive material, and dried simultaneously.
Powder layering of pellets-Layering a drug onto starter pellets.When the active ingredient is in powder form, pelletization can be achieved by spraying starter pellets with the active powder and at the same time a liquid binder solution. The layered pellets are then dried.
Melt granulation pelletization-Pelletization by heating and massing a powder mixture.Melt pelletization is performed in the active and binder powders are mixed and heated to a temperature above the melting point of the binder. Granulation and pelletization are then carried out in a single operation.
Wet granulation pelletization-Granulating and spheronizing a powder mixture.The active substance is mixed with 5-30% microcrystalline cellulose and the mixture granulated with water or an organic solvent. During the process the granules are compacted and spheronized.
PREPARATION OF PELLETS
-Drum/pan pelletization
- Extrusion-spheronization
-Centrifugal drug-layering
-Fluidized-bed pelletization
- High-shear melt pelletization
A-FLUID BED COATING BY WURSTER TECHNOLOGY
Innovative processes for Pellets / Particles coating
-Film coating /Enteric/ extended Release, and -lipid/hot melts coating.
-Coating of micro particles, granules, pellets
BATCH FLUID BED SYSTEMS categorized in different manufacturing Techniques:
-Top Spray Coating
-Bottom Spray Coating (Wurster Pellets Coating)
-Tangential Spray Coating (Rotor Pellet Coating)
PRINCIPLE OF OPERATION
With fluid bed coating, particles are fluidized and the coating/ Binder fluid sprayed on and dried. Small droplets and a low viscosity of the spray medium ensure an even product coating.
1-POWDER LAYERING PROCESS (ROTO SYSTEM)
2- COATING SUSPENSION AND SOLUTION LAYERING PROCESS
Article Written By: Md. Enamul Hoque Khan
Student of Mpharm,Department of Pharmacy,
East West University,Dhaka
Pelletization is an agglomeration process, that converts fine powder blend of drug(s) and excipients into small, free flowing, spherical units, referred to as pellets. (Ref. L. Hellen 1992)
The pelletizing process for the production of pharmaceutical pellets - including extrusion and spheronization, production of pellets by powder layering and liquid layering and pelletization via melt and wet granulation processes.
Why Pellet
-Excellent Stability
-Dust free Round pellets
-Good flow behavior
-Easy to dose
-Compact structure
-Very Low hygroscopicity
-High bulk density
-Dense, uniform surface
L-ow abrasion
-High active ingredient content possible
-Optimum starting shape for subsequent coating
-Controlled-release applications
- The risks of the local damage to the GI-tract mucosal
Some Type of Pellets
Liquid layering of pellets-coater systems can all be used to make pellets by layering the active material onto an inert core. Non-pareil starter pellets are sprayed with a solution or suspension of theactive material, and dried simultaneously.
Powder layering of pellets-Layering a drug onto starter pellets.When the active ingredient is in powder form, pelletization can be achieved by spraying starter pellets with the active powder and at the same time a liquid binder solution. The layered pellets are then dried.
Melt granulation pelletization-Pelletization by heating and massing a powder mixture.Melt pelletization is performed in the active and binder powders are mixed and heated to a temperature above the melting point of the binder. Granulation and pelletization are then carried out in a single operation.
Wet granulation pelletization-Granulating and spheronizing a powder mixture.The active substance is mixed with 5-30% microcrystalline cellulose and the mixture granulated with water or an organic solvent. During the process the granules are compacted and spheronized.
PREPARATION OF PELLETS
-Drum/pan pelletization
- Extrusion-spheronization
-Centrifugal drug-layering
-Fluidized-bed pelletization
- High-shear melt pelletization
A-FLUID BED COATING BY WURSTER TECHNOLOGY
 |
| Extrusion-Spheronizations of pellets |
Innovative processes for Pellets / Particles coating
-Film coating /Enteric/ extended Release, and -lipid/hot melts coating.
-Coating of micro particles, granules, pellets
BATCH FLUID BED SYSTEMS categorized in different manufacturing Techniques:
-Top Spray Coating
-Bottom Spray Coating (Wurster Pellets Coating)
-Tangential Spray Coating (Rotor Pellet Coating)
PRINCIPLE OF OPERATION
With fluid bed coating, particles are fluidized and the coating/ Binder fluid sprayed on and dried. Small droplets and a low viscosity of the spray medium ensure an even product coating.
 | |
| Fluid Bed Operation |
1-POWDER LAYERING PROCESS (ROTO SYSTEM)
2- COATING SUSPENSION AND SOLUTION LAYERING PROCESS
2- COATING SUSPENSION AND SOLUTION
LAYERING PROCESS
PROCESS PRINCIPLES
1- LAYERING
PROCESS-Film Coating
Article Written By: Md. Enamul Hoque Khan
Student of Mpharm,Department of Pharmacy,
East West University,Dhaka
Posted in: Pharmaceutical Technology
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